Prebiotics: Germinated barley foodstuff for the prevention of colitis-associated colon cancer?
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چکیده
منابع مشابه
Germinated barley foodstuff suppresses dextran sulfate experimental colitis in rats: the role of mast cells.
Recent studies have suggested that dietary fiber exerts a therapeutic effect on inflammatory bowel disease patients. The aim of this study was to evaluate the effects of a dietary fiber, germinated barley foodstuff (GBF), derived from the aleurone and scutellum fraction of germinated barley against dextran sulfate sodium (DSS)-induced experimental colitis in rats. Sprague-Dawley rats were fed a...
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The effects of germinated barley foodstuff (GBF) deriyed from the aleurone and scutell"m fractions of germinated barley low-lignified hemicellulose were examined in Spraglle-Dawley rats with constipation induced by loperamide by addition to the diet (2mg!kg body weight). Bowel moyements were higher in the GBF-fed rats than in the cellulose-fed rats used as a control. Fecal water content was als...
متن کاملModulation of intestinal environment by prebiotic germinated barley foodstuff prevents chemo-induced colonic carcinogenesis in rats.
Butyrate was shown to have a preventive effect on colon cancer in vivo. Germinated barley foodstuff (GBF) was in a prebiotic stage and had the potency to attenuate mucosal inflammation and to increase fecal butyrate production in colitis. This study aimed to determine whether the GBF treatment in a colon cancer model had the potency to suppress colon cancer. After a pre-feeding of either a cont...
متن کاملEffects of germinated barley foodstuff in preventing diarrhea and forming normal feces in ceco-colectomized rats.
Germinated barley foodstuff (GBF) derived from the aleurone and scutellum fractions of germinated barley was rich in glutamine and low-lignified hemicellulose. The diarrhea caused by ceco-colectomy could be prevented by feeding GBF to rats. GBF could also increase the protein content and sucrase activity of small intestinal mucosa in this model. This diarrhea-preventive effect of GBF would be b...
متن کاملMathematical model of colitis-associated colon cancer.
As a result of chronic inflammation of their colon, patients with ulcerative colitis or Crohn's disease are at risk of developing colon cancer. In this paper, we consider the progression of colitis-associated colon cancer. Unlike normal colon mucosa, the inflammed colon mucosa undergoes genetic mutations, affecting, in particular, tumor suppressors TP53 and adenomatous polyposis coli (APC) gene...
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ژورنال
عنوان ژورنال: Journal of Gastroenterology and Hepatology
سال: 2011
ISSN: 0815-9319
DOI: 10.1111/j.1440-1746.2011.06769.x